transgenesis : transgenic ( mouse, rat ) humanized

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Gene overexpression

Gene deletion

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genOway provides its customers with a high quality service, exemplified by the following benefits:

	Consultancy
	Fully customized service
	Flexibility
	Clear-cut guaranties
	Exclusive property of the model to the customer
	Animal facility subcontracted to a professional breeder: Charles River Laboratories
	Complementary services

Focusing its effort on the mouse and rat models, genOway has developed a complete range of technological solutions to overexpress (transgenic mouse, knock-in mouse,...) and to delete (constitutive knock out / knockout, conditional knock out / knockout,...) genes.

	The overexpression can be achieved by random integration of the gene in the genome of mouse and rat (transgenic mouse and rat), or by targeted insertion in a selected locus in the mouse or rat genome (knock-in).

	The deletion of the gene occurs in all tissues in constitutive knock out (knockout) models. In conditional knock out (knockout) models, the inactivation happens only in selected tissues or at a certain time during the animal development.

Inactivation (knock out / knockout) of genes and targeted overexpression (knock-in) are very important strategies for animal models. These strategies are only available in the mouse.
genOway is currently developing a rat knock out / knock-in program .